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Prasad Babanrao Phapale

Title

Associate Professor, PhD

Primary affiliation

Prasad Babanrao Phapale

Areas of expertise

  • Analytical Chemistry
  • Metabolomics
  • Spatial Omics
  • Computational Sciences
  • Imaging

Contact information

Telephone number
Email address

Profile

My Masters and Doctoral work was in Bioanalytical Chemistry and Metabolomics technology development for biomedical and environmental application. After initial experience in pharmaceutical drug discovery, I moved to EMBL Heidelberg, where I supported high-impact metabolomics research and co-developed widely used community resources. Since 2021, I have led BMBF funded independent research group at the Leibniz Institute for Analytical Sciences (ISAS Dortmund, Germany), focusing on spatial metabolomics, MALDI-MS imaging, isotope tracing, and multi-omics approaches to study metabolic heterogeneity in tissues, organoids, and environmental systems.

Research

I study how small molecules shape life in the environment and in human health. My research focuses on advancing Spatial Metabolomics and Mass Spectrometry Imaging (MSI) to understand how small molecules shape environmental and biomedical systems. By combining experimental omics with computational modeling, I develop workflows that map metabolic processes at cellular and temporal resolution. 

After initial experience in pharmaceutical drug discovery, I moved to EMBL Heidelberg, where I supported high-impact metabolomics research and co-developed widely used community resources. Since 2021, I have led BMBF funded independent research group at the Leibniz Institute for Analytical Sciences (ISAS Dortmund, Germany), focusing on spatial metabolomics, MALDI-MS imaging, isotope tracing, and multi-omics approaches to study metabolic heterogeneity in tissues, organoids, and environmental systems.

With the generous support of a Novo Nordisk Foundation RECRUIT grant, I am now establishing my spatial metabolomics research portfolio at Aarhus University, advancing applications in both environmental and biomedical sciences.

Teaching activities

I have always been passionate about training the next generation of scientists and leaders, combining both the experimental and theoretical aspects of my research. At Aarhus University, I have completed pedagogical training and contributed to teaching and mentoring in analytical chemistry, omics sciences, and computational approaches. 

I am actively involved in supervising PhD, postdoctoral, and master’s projects, ensuring that students gain hands-on experience with cutting-edge techniques in metabolomics and mass spectrometry. 

Collaborations

My research spans biomedical sciences, environmental science, biochemistry, computational sciences and technology development, with applications across health and sustainability. This of course requires highly interdisciplinary collaborations and extensive co-ordination with multi-partner projects, bringing together academic, clinical, and industry partners to advance metabolomics, imaging, and omics integration. My team is extensively international with research partners across Europe, Asia, India, and the US, and have built a strong network of collaborators throughout my career. During my time at the European Molecular Biology Laboratory (EMBL Heidelberg), we contributed to and supported research funded by major agencies, including BMBF, Novo Nordisk Foundation, DFG, Chan Zuckerberg Initiative, and ERC. 

At Aarhus University, I continue interdisciplinary, cross-border and cross-sector partnerships, and I am always open to collaboration in advancing metabolomics, omics integration, and novel imaging technologies.

Consultancy

I began my career in pharmaceutical R&D and later helped pioneer pharmaco-metabolomics, linking drug metabolism (DMPK) to patient responses. I worked extensively on combining DMPK with omics Biomarker technologies to help drug discovery research. During my time at EMBL Heidelberg, I established the Metabolomics Core Facility, generating high-impact publications and co-developing widely used analytical and computational tools. 

Job responsibilities

I lead the Spatial Metabolomics research, focusing on cutting-edge research in metabolomics, lipidomics, and mass spectrometry imaging. My responsibilities include securing competitive research funding, building and managing an advanced laboratory, and mentoring PhD students, postdocs, and early-career researchers. Also developing interdisciplinary collaborations across biomedicine, environmental science, and technology, while contributing to scientific leadership and innovation within the department.

Selected publications

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Selected projects

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