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Institut for Biologi

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Følg med i de senest publicerede videnskabelige artikler fra Institut for Biologi. Oversigten viser Instituttets publikationer med de nyeste øverst:

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Dubin, A., Travis, J., Enghild, J. J. & Potempa, J. (1992). Equine leukocyte elastase inhibitor. Primary structure and identification as a thymosin-binding protein. Journal of Biological Chemistry, 267(10), 6576-83.

Mast, A. E., Enghild, J. J., Nagase, H., Suzuki, K., Pizzo, S. V. & Salvesen, G. (1991). Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin). Journal of Biological Chemistry, 266(24), 15810-6.

Mast, A. E., Enghild, J. J., Pizzo, S. V. & Salvesen, G. (1991). Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, antithrombin III, alpha 2-antiplasmin, angiotensinogen, and ovalbumin. Biochemistry, 30(6), 1723-30.

Rubenstein, D. S., Enghild, J. J. & Pizzo, S. V. (1991). Limited proteolysis of the alpha-macroglobulin rat alpha 1-inhibitor-3. Implications for a domain structure. Journal of Biological Chemistry, 266(17), 11252-61.

Nagase, H., Ogata, Y., Suzuki, K., Enghild, J. J. & Salvesen, G. (1991). Substrate specificities and activation mechanisms of matrix metalloproteinases. Biochemical Society. Transactions, 19(3), 715-8.

Cooper, D. L., Baptist, E. W., Enghild, J. J., Isola, N. R. & Klintworth, G. K. (1991). Bovine corneal protein 54K (BCP54) is a homologue of the tumor-associated (class 3) rat aldehyde dehydrogenase (RATALD). Gene, 98(2), 201-7.

Salvesen, G. & Enghild, J. J. (1993). alpha-Macroglobulins: detection and characterization. Methods in Enzymology, 223, 121-41.

Gonzalez-Gronow, M., Enghild, J. J. & Pizzo, S. V. (1993). Streptokinase and human fibronectin share a common epitope: implications for regulation of fibrinolysis and rheumatoid arthritis. BBA General Subjects, 1180(3), 283-8.

Rubenstein, D. S., Thøgersen, I. B., Pizzo, S. V. & Enghild, J. J. (1993). Identification of monomeric alpha-macroglobulin proteinase inhibitors in birds, reptiles, amphibians and mammals, and purification and characterization of a monomeric alpha-macroglobulin proteinase inhibitor from the American bullfrog Rana catesbeiana. Biochemical Journal, 290 ( Pt 1), 85-95.

Enghild, J. J., Salvesen, G., Thøgersen, I. B., Valnickova, Z., Pizzo, S. V. & Hefta, S. A. (1993). Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. Journal of Biological Chemistry, 268(12), 8711-6.

Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S. & Roses, A. D. (1993). Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proceedings of the National Academy of Sciences (PNAS), 90(5), 1977-81.

Chu, C. T., Oury, T. D., Enghild, J. J. & Pizzo, S. V. (1994). Adjuvant-free in vivo targeting. Antigen delivery by alpha 2-macroglobulin enhances antibody formation. Journal of Immunology, 152(4), 1538-45.

Enghild, J. J., Valnickova, Z., Thøgersen, I. B. & Pizzo, S. V. (1994). Complexes between serpins and inactive proteinases are not thermodynamically stable but are recognized by serpin receptors. Journal of Biological Chemistry, 269(31), 20159-66.

Falkenberg, C., Enghild, J. J., Thøgersen, I. B., Salvesen, G. & Akerström, B. (1994). Isolation and characterization of fibronectin-alpha 1-microglobulin complex in rat plasma. Biochemical Journal, 301 ( Pt 3), 745-51.

Fowlkes, J. L., Enghild, J. J., Suzuki, K. & Nagase, H. (1994). Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures. Journal of Biological Chemistry, 269(41), 25742-6.

Falkenberg, C., Allhorn, M., Thøgersen, I. B., Valnickova, Z., Pizzo, S. V., Salvesen, G., Akerström, B. & Enghild, J. J. (1995). alpha 1-Microglobulin destroys the proteinase inhibitory activity of alpha 1-inhibitor-3 by complex formation. Journal of Biological Chemistry, 270(9), 4478-83.

Akerström, B., Bratt, T. & Enghild, J. J. (1995). Formation of the alpha 1-microglobulin chromophore in mammalian and insect cells: a novel post-translational mechanism? FEBS Letters, 362(1), 50-4.

Moser, T. L., Enghild, J. J., Pizzo, S. V. & Stack, M. S. (1995). Specific binding of urinary-type plasminogen activator (u-PA) to vitronectin and its role in mediating u-PA-dependent adhesion of U937 cells. Biochemical Journal, 307 ( Pt 3), 867-73.

Ren, X. D., Dodds, A. W., Enghild, J. J., Chu, C. T. & Law, S. K. (1995). The effect of residue 1106 on the thioester-mediated covalent binding reaction of human complement protein C4 and the monomeric rat alpha-macroglobulin alpha 1 I3. FEBS Letters, 368(1), 87-91.

Thøgersen, I. B. & Enghild, J. J. (1995). Biosynthesis of bikunin proteins in the human carcinoma cell line HepG2 and in primary human hepatocytes. Polypeptide assembly by glycosaminoglycan. Journal of Biological Chemistry, 270(31), 18700-9.

Enghild, J. J., Valnickova, Z., Thøgersen, I. B., Pizzo, S. V. & Salvesen, G. (1993). An examination of the inhibitory mechanism of serpins by analysing the interaction of trypsin and chymotrypsin with alpha 2-antiplasmin. Biochemical Journal, 291 ( Pt 3), 933-8.

Christensen, S., Valnickova, Z., Thøgersen, I. B., Pizzo, S. V., Nielsen, H. R., Roepstorff, P. & Enghild, J. J. (1995). Sodium dodecyl sulfate-stable complexes between serpins and active or inactive proteinases contain the region COOH-terminal to the reactive site loop. Journal of Biological Chemistry, 270(25), 14859-62.

Potempa, J., Enghild, J. J. & Travis, J. (1995). The primary elastase inhibitor (elastasin) and trypsin inhibitor (contrapsin) in the goat are serpins related to human alpha 1-anti-chymotrypsin. Biochemical Journal, 306 ( Pt 1), 191-7.

Jensen, C. H., Krogh, T. N., Højrup, P., Clausen, P. P., Skjødt, K., Larsson, L. I., Enghild, J. J. & Teisner, B. (1994). Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2. FEBS journal, 225(1), 83-92.

Achyuthan, K. E., Slaughter, T. F., Santiago, M. A., Enghild, J. J. & Greenberg, C. S. (1993). Factor XIIIa-derived peptides inhibit transglutaminase activity. Localization of substrate recognition sites. Journal of Biological Chemistry, 268(28), 21284-92.

Moser, T. L., Enghild, J. J., Pizzo, S. V. & Stack, M. S. (1993). The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. Journal of Biological Chemistry, 268(25), 18917-23.

Brouwer, M., Enghild, J., Hoexum-Brouwer, T., Thøgersen, I. & Truncali, A. (1995). Primary structure and tissue-specific expression of blue crab (Callinectes sapidus) metallothionein isoforms. Biochemical Journal, 311 ( Pt 2), 617-22.

Burke, J. R., Enghild, J. J., Martin, M. E., Jou, Y. S., Myers, R. M., Roses, A. D., Vance, J. M. & Strittmatter, W. J. (1996). Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nature Medicine, 2(3), 347-50.

Valnickova, Z., Thøgersen, I., Christensen, S., Chu, C. T., Pizzo, S. V. & Enghild, J. J. (1996). Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein. Journal of Biological Chemistry, 271(22), 12937-43.

Ito, A., Mukaiyama, A., Itoh, Y., Nagase, H., Thøgersen, I., Enghild, J. J., Sasaguri, Y. & Mori, Y. (1996). Degradation of interleukin 1beta by matrix metalloproteinases. Journal of Biological Chemistry, 271(25), 14657-60.

Oury, T. D., Crapo, J. D., Valnickova, Z. & Enghild, J. J. (1996). Human extracellular superoxide dismutase is a tetramer composed of two disulphide-linked dimers: a simplified, high-yield purification of extracellular superoxide dismutase. Biochemical Journal, 317 ( Pt 1), 51-7.

Grøn, H., Thøgersen, I. B., Enghild, J. J. & Pizzo, S. V. (1996). Structural and functional analysis of the spontaneous re-formation of the thiol ester bond in human alpha 2-macroglobulin, rat alpha 1-inhibitor-3 and chemically modified derivatives. Biochemical Journal, 318 ( Pt 2), 539-45.

Gately, S., Twardowski, P., Stack, M. S., Patrick, M., Boggio, L., Cundiff, D. L., Schnaper, H. W., Madison, L., Volpert, O., Bouck, N., Enghild, J., Kwaan, H. C. & Soff, G. A. (1996). Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor, angiostatin. Cancer Research, 56(21), 4887-90.

Mak, P., Enghild, J. J. & Dubin, A. (1996). Hamster antithrombin III: purification, characterization and acute phase response. Comparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology, 115(1), 135-41.

Pirie-Shepherd, S. R., Stevens, R. D., Andon, N. L., Enghild, J. J. & Pizzo, S. V. (1997). Evidence for a novel O-linked sialylated trisaccharide on Ser-248 of human plasminogen 2. Journal of Biological Chemistry, 272(11), 7408-11.

Grøn, H., Pike, R., Potempa, J., Travis, J., Thøgersen, I. B., Enghild, J. J. & Pizzo, S. V. (1997). The potential role of alpha 2-macroglobulin in the control of cysteine proteinases (gingipains) from Porphyromonas gingivalis. Journal of Periodontal Research, 32(1 Pt 1), 61-8.

Christensen, S., Valnickova, Z., Thøgersen, I., Olsen, E. H. & Enghild, J. J. (1997). Assignment of a single disulphide bridge in human alpha2-antiplasmin: implications for the structural and functional properties. Biochemical Journal, 323 ( Pt 3), 847-52.

Berggård, T., Thelin, N., Falkenberg, C., Enghild, J. J. & Akerström, B. (1997). Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma. FEBS journal, 245(3), 676-83.

Brouwer, M., Brouwer, T. H., Grater, W., Enghild, J. J. & Thøgersen, I. (1997). The paradigm that all oxygen-respiring eukaryotes have cytosolic CuZn-superoxide dismutase and that Mn-superoxide dismutase is localized to the mitochondria does not apply to a large group of marine arthropods. Biochemistry, 36(43), 13381-8. https://doi.org/10.1021/bi971052c

Folz, R. J., Guan, J., Seldin, M. F., Oury, T. D., Enghild, J. J. & Crapo, J. D. (1997). Mouse extracellular superoxide dismutase: primary structure, tissue-specific gene expression, chromosomal localization, and lung in situ hybridization. American Journal of Respiratory Cell and Molecular Biology, 17(4), 393-403.

Gately, S., Twardowski, P., Stack, M. S., Cundiff, D. L., Grella, D., Castellino, F. J., Enghild, J., Kwaan, H. C., Lee, F., Kramer, R. A., Volpert, O., Bouck, N. & Soff, G. A. (1997). The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin. Proceedings of the National Academy of Sciences (PNAS), 94(20), 10868-72.

Moser, T. L., Stack, M. S., Asplin, I., Enghild, J. J., Højrup, P., Everitt, L., Hubchak, S., Schnaper, H. W. & Pizzo, S. V. (1999). Angiostatin binds ATP synthase on the surface of human endothelial cells. Proceedings of the National Academy of Sciences (PNAS), 96(6), 2811-6.

Berggård, T., Enghild, J. J., Badve, S., Salafia, C. M., Lögdberg, L. & Akerström, B. (1999). Histologic distribution and biochemical properties of alpha 1-microglobulin in human placenta. American Journal of Reproductive Immunology, 41(1), 52-60.

Stack, M. S., Gately, S., Bafetti, L. M., Enghild, J. J. & Soff, G. A. (1999). Angiostatin inhibits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation. Biochemical Journal, 340 ( Pt 1), 77-84.

Enghild, J. J., Thøgersen, I., Oury, T. D., Valnickova, Z., Hojrup, P. & Crapo, J. D. (1999). The heparin-binding domain of extracellular superoxide dismutase is proteolytically processed intracellularly during biosynthesis. Journal of Biological Chemistry, 274(21), 14818-22.

Fishman, D. A., Kearns, A., Larsh, S., Enghild, J. J. & Stack, M. S. (1999). Autocrine regulation of growth stimulation in human epithelial ovarian carcinoma by serine-proteinase-catalysed release of the urinary-type-plasminogen-activator N-terminal fragment. Biochemical Journal, 341 ( Pt 3), 765-9.

Enghild, J. J., Thøgersen, I. B., Cheng, F., Fransson, L. A., Roepstorff, P. & Rahbek-Nielsen, H. (1999). Organization of the inter-alpha-inhibitor heavy chains on the chondroitin sulfate originating from Ser(10) of bikunin: posttranslational modification of IalphaI-derived bikunin. Biochemistry, 38(36), 11804-13.

Klintworth, G. K., Valnickova, Z., Kielar, R. A., Baratz, K. H., Campbell, R. J. & Enghild, J. J. (1997). Familial subepithelial corneal amyloidosis- a lactoferrin-related amyloidosis. Investigative Ophthalmology & Visual Science, 38(13), 2756-63.

Olsen, E. H., Rahbek-Nielsen, H., Thøgersen, I., Roepstorff, P. & Enghild, J. J. (1998). Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2. Biochemistry, 37(1), 408-16. https://doi.org/10.1021/bi971137d

Klintworth, G. K., Valnickova, Z. & Enghild, J. J. (1998). Accumulation of beta ig-h3 gene product in corneas with granular dystrophy. American Journal of Pathology, 152(3), 743-8.

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Anne Kirstine Mehlsen